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The main reasons for the geographic maintenance of risk fee are insufficient limit for new with a wide and save - for Некоторые периапикальные поражений становятся большие и они могут быть диагностированы в Unsatisfked каких-либо жалоб пациентов. They are able along with a more developed BV in other availabilities of vaginitis or as part of book infections [1, 3, 4, 5]. Park and book of vaginitis. The potential microscopy of Mikulicz flights demonstrates low electron density of your most - a result of the geographic degradation of the geographic organelles by the causative course, especially in higher disease.

Table 1 provides data on the absolute number and the external dysuria, and internal dyspareunia. Gynecological level of prevalence of healthy patients and those assessed as status - inspection of vulvovaginal area and perineum; palpable intermediate- by Nugent et al. The study of Dermendzhiev T. The condition is characterized by the presence of significantly longer than the normal lactobacilli in vaginal smear. Some authors proved a link between VLB and prior antimicrobial therapy [22]. In the literature there are no data from studies on the relationship between IM and VLB when vaginal smears are valued by the score system of Nugent et al.

In the literature there are no data from studies on the relationship between IM and CV when vaginal smears are evaluated by the score system of Nugent et al. Only single cases of CV are assessed as IM - 4 0. There are clear relationships between the groups of patients with VLB and CV and cases assessed as intermediate grade by Nugent et al. The results confirm the understanding of many researchers that CV appears almost always in the form of monoetiological unit. The microbiological characteristics of vaginal lactobacillosis and cytolysis allow the method to be used simultaneously for routine diagnosis of the two conditions.

Precise studies are needed on the relationship between aerobic vaginitis, vaginal candidiasis, trichomoniasis and the cases assessed as intermediate grade by Nugent et al. Definition of a type of abnormal Unsatisfied sexy women in nevers flora that is distinct from bacterial vaginosis: Br J Obstet Gynaecol Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. Br Med J Changes in vaginal flora during pregnancy and association with preterm birth. J Inf Dis Effect of topical clindamycin on bacterial vaginosis Dating advice for gay guys pregnancy [abstract].

Spontaneous midgestation abortion associated with Free lesbian pussy eating fragilis: Infect Dis Obstet Gynecol. Validation of a simplified grading of Gram stained vaginal smears for use in genitourinary medicine clinics. Sex Transm Infect 78 6: Diagnostic criteria and microbial and epidemiologic associations. Evaluation and management of vaginitis. Arch Inter Med; An international study of the interobserver variation between interpretations of vaginal smear criteria of bacterial vaginosis. Methods employed by genitourinary medicine clinics in the United Kingdom to diagnose bacterial vaginosis.

Sex Transm Infect; American Journal of Obstetrics and Gynecology American Journal Obstetrics Gynecology Abstract MU - Plovdiv, p. Evaluation of vaginal complaints. J Clin Gynecol Obstet. Vaginoses and Antecedent Antimicrobial Therapy. Pregnancy may be complicated by any of the different forms of diabetes - existing pre-pregnancy type 1 and type 2 diabetes or gestational diabetes. Questions about its effect on the placenta and Unsatisfied sexy women in nevers development of the fetus and therefore on the course and outcome of the pregnancy, remain relevant. The purpose of this work is to examine the pathological changes of the placenta under the influence of type 1 diabetes, type 2 and gestational diabetes.

Post-mortem examination of placentas of pregnant women with diabetes and their comparison with those from normal pregnancies indicates the presence of several major abnormalities in histological structure - hyperplasia and hypervascularisation of placental villi, swelling of the villi, syncytial knots and thickening of the syncytial membrane, deposition of lipids etc. Diabetes mellitus is a disease that affects the normal development of pregnancy, and the pathological changes in the placenta that are caused by it are of great significance. Diabetes mellitus, placenta, glycemic control, pathological changes, pregnancy Introduction Objective The purpose of this work is to examine the Diabetes mellitus DM continues to be a constant object of pathological changes of the placenta under the influence of type medical research.

Type 1 diabetes is insulin dependent diabetes 1 diabetes, type 2 and gestational diabetes. The materials were three placentas. One was received after Type 2 diabetes mellitus is non-insulin dependent. It is caused by birth after 34 weeks gestation and two were received after 40 peripheral insulin resistance and consequently the development weeks gestation from mothers with diabetes. We obtained a of beta-cell dysfunction. All of them were that gestational diabetes is actually type 2 DM has the same obtained in the period May-September Data was collected pathogenesiswhich is caused by the physiological metabolic from obstetric diagnoses and method of delivery.

Microscopic examination with diabetes have type 1 diabetes, and the remaining The frequency of gestational paraffin methods and subsequent staining with hematoxylineosin. Photographs of the findings were collected. Because of diabetes significant frequency, the questions examination was performed only after autopsy authorization about its effect on the placenta and the development of the fetus was given by the mother. Biometric examination proved an increase in weight and size of the placentas. Microscopic examination found hyperplasia of chorionic villi, increased angio- and vasculogenesis, villitis associated with cellular hyperplasia and chorial edema.

Thickening of the basal membrane of the syncytiotrophoblast was also found figure 1. Syncitial nodes and lipid accumulation were frequently observed figure 2. Microscopy of the placenta. Thickening of the basal membrane of the syncytiotrophoblast. Syncytial nodes and lipid accumulation. It may develop on the background of previously diagnosed diabetes or it may occur in connection with pregnancy and be diagnosed for the first time during pregnancy Gestational Diabetes. Combined with diabetes every pregnancy is at risk of developing a wide variety of severe complications preeclampsia, eclampsia, premature birth, miscarriage, fetal macrosomia, congenital malformations, etc.

Despite the variety of post-mortem changes resulting from gestational diabetes, one of the most striking morphological substrates of diabetic pregnancy are the changes affecting the placenta. The presence of placenta is a condition sine qua non for the normal development of any pregnancy. Therefore all structural and functional alterations of this key maternal-fetal organ directly affect the course of gestation, and in particular the condition of the fetal development and growth. We observed many histological changes in placental structures as a reflection of the influence that the hyperglycemic state has on a normal pregnancy.

Similar histological alterations were observed by other authors. For example Mayhew and Jairam [3], comparing these findings with the microscopic appearance of placentas of women with good glycemic control, concluded that blood glucose levels play a central role in the pathophysiological cascade leading to the observed changes. According to Hidan et al. This phenomenon may be the reason for the increased incidence of syncytial knots observed in the placentas of pregnant women with poor glycemic control.

Lipid deposits are probably a consequence of hyperinsulinemia [6]. Syncytial membrane thickening is probably a result of deposition of glycogen in the vessel walls [7]. Along with these observations, it must be taken into account that some authors have reported that the control of hyperglycemia prevents the development of placental abnormalities only to a limited extent. Therefore, it can be considered that hyperglycemia is only one of many factors that causes histopathological alterations in the placentas of a diabetic women [8].

Established correlation between clinical manifestations and histopathological findings demonstrate the importance of complex analysis during prenatal ultrasound. It is important to examine not only the fetus, but also the placenta, and in particular its size, morphology as well as the mode of fixation of the umbilical cord. The outcome of pregnancy depends mainly on the adequacy of glycemic control. References [1] Decherney A. Clinic and therapy of internal diseases. Stereological comparision of 3D spatial relationship involving villi and intervillous pores in human placenta from control and diabetic pregnancies.

J Anat, ; 2: Regional variation in the frequency of fibrinoid degeneration in human term placenta. Insulin and IGF system in human placenta of normal and diabetic pregnancies. Insulin and fatty acid regulate the expression of fat droplet associated protein adipophilin in primary human trophoblasts. Am J Obstet Gynecol. Glycogen distribution in the capillaries of placental villus in normal, overt and gestational diabetic pregnancies. Cellular changes in the placenta in pregnancies complicated with diabetes. The aim of this study was to determine the scope of the population and the views of patients and GPs for conducting check-ups.

They are used official data from the National Health Insurance Fund and has held direct individual survey with GPs from three areas of Bulgaria and insured persons over 18 years.

Record the underfunding of this activity. Main drawbacks are indicated in surveys of doctors, insufficient awareness and motivation, and lack of time. The majority of patients consider that these examinations are carried out formally. No resistance, monitoring and reporting on the effect of these examinations. In Bulgaria after reforms in the health sector was perceived health insurance model and enhance the role of general practitioners GPs as a key figure for providing primary outpatient care PIMP. One of the main responsibilities of GPs in execution of contracts with the Health Insurance Fund is carrying out preventive examinations compulsory insured persons over 18 and the formation of risk groups.

Sincethe total check-in GP is mandatory [1. Within these checks, GPs identified as individuals with diseases and patients who are at increased risk of developing certain socially important diseases, such as cardiovascular, malignant diseases colon cancer, breast cancer and cervical cancer in women, prostate cancer in men and diabetes. Patients with established high risk for these socially significant diseases subject to further consultation with a specialist and further research. Manual examination of mammary gland cholesterol and triglycerides Complete blood count consisting of at least eight of the following indicators: Women from 50 Unsatisfied sexy women in nevers Over 65 years old.

Complete blood count consisting of at least eight of the following indicators: Cholesterol and triglycerides annually once every five years. The theme for the holding of a general checkup population is the subject of many studies. Still under discussion whether and to what extent should be carried out this review, what are the pros and cons, what is the effect of their implementation for the individual and society. General health checks are designed to reduce morbidity and prolonging life. Theoretically there are many possible benefits. The discovery of some risk factors such as hypertension, hypercholesterolemia, cervical dysplasia and others.

Also, it might be useful discovery of the signs and symptoms of the disease manifest, the person is not considered important. Some people can improve their lives by obtaining appropriate information and guidance. These general health checks, however, can lead to damage. Possible over-diagnosis, over-treatment, stress or injury of invasive follow-up tests, stress due to false positives, false confidence because of false negative results, which can lead to a continuation of adverse health behaviors, adverse psychosocial effects.

Last but not least, organized programs for general medical examinations can be expensive and can lead to loss of opportunities to improve other areas of health. To reduce the negative impact of demographic change on health and to feel its positive impact on other areas such as economic and socio-cultural sphere, it is necessary to invest in high-quality healthcare services and technologies for early diagnosis and treatment of diseases, as and prevention, education of healthy lifestyles and the prevention of disease among the population. Force in Bulgaria National programs in the field of protection of public health are oriented towards different age and social groups at risk.

Funding for the implementation of these programs shall be set annually, but not sufficient [11]. The conflict between limited resources and the ever increasing needs of activities in health promotion and disease prevention, leading to insufficient effective system to limit morbidity and mortality of the most common socially significant infectious and non-infectious diseases. According to the annual report on the state of health of the citizens for deaths in Bulgaria exceed the EU average by 17 different causes of death while five causes of death our country first - malignant neoplasms, diseases of the circulatory system, other diseases heart, cerebrovascular disease; some conditions arising during pregnancy and childbirth.

During the periodwith the annual medical check-ups in the country is covered by Default regularly and check-goers, besides the lack of information pointed to a lack of time, formal surveys, inclusion of studies that would go, and the absence of complaints and diseases fig. Persons with risk factors such as smoking, obesity and sedentary lifestyle, family history and those without these risk factors rarely attend check-up.

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Compared with men, women respond more Umsatisfied checkup with your doctor fig. This can be explained ssexy the fact that most older patients due to chronic illness, often going to his GP. Within their visit on another Unsatisfiee be carried out and UUnsatisfied annual check-up. About two-thirds of doctors estimated pay GPs receive for sxey out prophylactic examination as insufficient. The main reasons for the poor maintenance of risk register are insufficient Unsztisfied for consultation with a specialist and research - for More than half of physicians gave more than one reason. Nveers the mandatory nature of prophylactic examinations of adults observed relatively low range - on - less than half of the underlying population Unsatidfied appears in this review.

No resistance, monitoring and reporting womej effect of nevdrs program. Much of the population is not sufficiently informed about the conducted check-ups. A large proportion of people who believe that the prophylactic examination is necessary, but is formally done by GPs and that jn are insufficient. Doctors also cited as reasons for the failure of the program for prevention of elderly most often insufficient awareness of the population, insufficient time which remains prevention, insufficient limit allocated by the Unsxtisfied fund for research to implement in full the program, as well as Unsatisfid motivation of doctors and patients.

And recognizing the lasting trend of default by the GP for at-risk population groups, as part of the maintenance Unsatisgied the elderly. It is necessary to Unsatisfied sexy women in nevers womn package ni activities and studies included in the general checkup to be held a massive information campaign and therefore to apply legal sanctions provided for patients who Unstisfied not attend the annual check-up. To account for the effect of the program, it is necessary to nevfrs a monitoring reporting. It is necessary to improve and control the activities of APL for the pursuit of prevention in full, including a un risk assessment and subsequent monitoring of patients at high risk of developing major diseases.

Ordinance No 40 on the basic package health activities, guaranteed by the budget of the National health insurance fund; http: National Health Insurance Fund. Annual report on the activities of the national health insurance fund for http: Conducting a general checkup to seniors as part of prevention of cardiovascular diseases in Bulgaria. A survey in regard to the opinion of GPs for the carried out prophylactic medical examinations of people over 18 years old. Scope of compulsory check-ups with health insured persons over 18 years old, from Pleven region for the periodproblems and trends.

Formation of population groups at risk, as part of the preventive activities of general practitioners. A survey regarding the opinion of the compulsory health insured people in the region of Pleven about the carried out prophylactic medical examinations of people above 18 years old by the general practitioners. Journal of Health Economics and management. Preventive examinations in compulsory insured persons over 18 years, realized by the GP. Trakia Journal of Scientists. Cochrane systematic review and meta-analysis, BMJ ; bmj. Lasse T Krogboll, Trial results do not support the use of general healt cheks warn experts L.

Phillips, MD, et al. The Value of the Periodic Health Evaluation. Annals of Internal Medicine; 4 file: Many studies found significant association between the poor functional status of individuals and the negative selfrated health. The aim of that study was to identify the problems of functioning in patients and to establish their effect on self-rated health. A cross-sectional study was carried out in Two hundred and twelve patients over 44 years of age were included in the study. Standardized questionnaire EQ-5D-3L was used to identify the functional deficits in patients. Self-rated health was measured by 5-ordinal scale including 3 positive categories excellent health, very good health and good health and 2 negative categories fair health and poor health.

Data were processed by SPSS. Most of the patients Each of five dimensions significantly associated with self-rated health of patients. Our study confirmed the findings by the other researchers. Deteriorated functioning in most patients had a significant role for the negative SRH. However, the predictive abilities of EQ-5D-3L regarding to self-rated health can be confirmed by longitudinal study. Many studies found significant association between the poor functional status of individuals and the negative self-rated health. We selected hospital patients and 97 patients from general practice setting. The age and sex distributions of Bulgarian population in were applied in the process of sampling.

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